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Stay in Santa Cruz Region's best hotels!

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Wonderful: 9+ Very Good: 8+ Good: 7+ Pleasant: 6+
Our top picks Lowest Price First Star rating and price Top reviewed

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Cosmopolitano Hotel Boutique

Hotel in Santa Cruz de la Sierra

Offering an outdoor pool, Cosmopolitano Hotel Boutique is located in the historical center of Santa Cruz de la Sierra. Guests can enjoy the on-site bar. Service was impeccable. We had to leave at 4:00 am in the morning to catch our flight and they made a full breakfast for us before we left.

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9.1
Wonderful
1,078 reviews
Price from
$72.23
per night

Chairu Eco Hotel

Hotel in Santa Cruz de la Sierra

Chairu Eco Hotel features an outdoor swimming pool, shared lounge, a terrace and restaurant in Santa Cruz de la Sierra. Located where I expected to be, as I need to fix some issues in the town, and the office was closer to the hotel. Did not have time to enjoy as my stay was quite short. and left before breakfast. Area is quite safe and I have walked during the night, returing from a chinese restaurant and it was OK.

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9
Wonderful
820 reviews
Price from
$60
per night

TRYP by Wyndham Santa Cruz

Hotel in Santa Cruz de la Sierra

Located in Santa Cruz de la Sierra, a 19-minute walk from Gabriel Rene Moreno Autonomous University, TRYP by Wyndham Santa Cruz has accommodations with an outdoor swimming pool, free private parking,... Great location. Friendly staff.

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9.1
Wonderful
531 reviews
Price from
$69
per night

YVY CASA HOTEL

Hotel in Samaipata

Located in Samaipata, 6.1 miles from Samaipata Fort, YVY CASA HOTEL provides accommodations with a garden, free private parking and a terrace. Impeccable service, great ambience, delicious breakfast, spacious rooms with direct access to the outside. Everything is cared for- the soap, the drinking water. Highest recommendations!

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9.1
Wonderful
378 reviews
Price from
$39.60
per night

Marriott Santa Cruz de la Sierra Hotel

Hotel in Santa Cruz de la Sierra

Marriott Santa Cruz de la Sierra Hotel has an outdoor swimming pool, fitness center, a shared lounge and terrace in Santa Cruz de la Sierra. Nice spacious rooms. Gym and pool available. Very nice breakfast. Friendly staff

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9.1
Wonderful
363 reviews
Price from
$104.25
per night

La Vida es Bella

Hotel in Samaipata

Located in Samaipata, 5.6 miles from Samaipata Fort, La Vida es Bella provides accommodations with a garden, free private parking, a shared lounge and a terrace. Beautiful place! Really quiet and relaxing and the staff was so helpful and kind. Can't recommend this place enough and we look forward to come back!

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9.1
Wonderful
105 reviews
Price from
$60
per night

El Pueblito Hotel Boutique

Hotel in Samaipata

Located in Samaipata, 7 miles from Samaipata Fort, El Pueblito Hotel Boutique has accommodations with an outdoor swimming pool, free private parking, a garden and a shared lounge. Very charming property with super friendly staff

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9.4
Wonderful
217 reviews
Price from
$87
per night

Alfonsina Hotel Boutique

Hotel in Santa Cruz de la Sierra

Conveniently located only a 10-minute walk from Ventura Shopping Center, Alfonsina Hotel Boutique. offers accommodations in Santa Cruz de la Sierra. Loved the decor with all the photos and cool items in all areas of hotel. Food and staff were very friendly and helpful. Room was Spacious and clean. Felt safe in area to walk to restaurants

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9.3
Wonderful
415 reviews
Price from
$135
per night

Hotel Cortez

Hotel in Santa Cruz de la Sierra

Boasting an outdoor swimming pool, gym and spa facilities, Hotel Cortez has chic and spacious rooms in Santa Cruz de la Sierra. Free WiFi access is available. Everthing was excellent, the facilities and the food. And the staff was super, friendly and helpfull.

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9.3
Wonderful
191 reviews
Price from
$117
per night

Hotel By Armonía Santa Cruz

Hotel in Santa Cruz de la Sierra

Located in Santa Cruz de la Sierra, a 19-minute walk from Güembé Biocentre and Guazú Ivaga Park, Hotel By Armonía Santa Cruz has accommodations with an outdoor swimming pool, free private parking, a... Great location although away from the city center but quiet and peaceful. The whole team at the Armonia is very friendly and attentive. The breakfast was delicious. The room was spacious, nicely decorated and very clean. I can recommend Hotel by Armonia to anybody and would certainly stay there again.

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9.3
Wonderful
62 reviews
Price from
$76.50
per night

Hotels with extra health and safety measures

Find hotels in Santa Cruz Region with added hygiene measures plus high cleanliness ratings

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