Skip to main content

Featured guest house destinations

Destination inspiration for your trip – find a guest house

The best guest houses in Santa Cruz Region

Check out our pick of great guest houses in Santa Cruz Region

Filter by:


Review score

Superb: 9+ Very good: 8+ Good: 7+ Pleasant: 6+
Our top picks Lowest price first Star rating and price Top reviewed

See the latest prices and deals by choosing your dates.

Hostel Serena

Samaipata

Some units in the guest house have private entrance and are fitted with desk and wardrobe. Units come with a safety deposit box, while some rooms also feature a terrace and others also feature mountain views. At the guest house, every unit is equipped with bed linen and towels. The vibe was just amazing. Calm, friendly, and homey.

Show more Show less
9.5
Exceptional
422 reviews
Price from
£13
per night

Travelero Hostel & Tours

Santa Cruz de la Sierra

Situated in Santa Cruz de la Sierra, within less than 1 km of Arenal Park and a 14-minute walk of 24th of September Metropolitan Plaza, Travelero Hostel & Tours features accommodation with an outdoor swimming pool and free WiFi as well as free private parking for guests who drive. Featuring a garden, the guest house is close to several noted attractions, around 1.4 km from Sacred Art Museum and around 1.2 km from Metropolitan Cathedral. Boasting family rooms, this property also provides guests with a terrace. Such a good hostel. Clean, nice staff. Good pool and location! Fairly social too. Gym opposite too!

Show more Show less
9
Superb
39 reviews
Price from
£10
per night

Casa del Telegrafista

La Higuera

Casa del Telegrafista features a garden, terrace, a restaurant and bar in La Higuera. Featuring family rooms, this property also provides guests with a barbecue. The accommodation provides room service, a tour desk and currency exchange for guests.

At the inn, each room includes a patio with a mountain view. By far the best experience I have had in Bolivia after 3 months of traveling here. The hostel is both in a unique location in nature with lots of peace, incredible starry skies, a mountain view that is unparalleled. In addition, the French host family is located in a historic area and is very well informed about the historical relevance of the region and can tell a lot about it (Ché Guevara). They were also able to spontaneously organize transportation and a reliable guide who was able to lead us on adventurous and natural paths to the commemorative site for "The Comandante". Outstanding is also the food, the host really takes a lot of time and is a real heart person. I got a little sick during the trip and the family took care of me like I was part of them. A safe haven and a unique stay. People often book only one or two nights and yet then stay a whole week, I can only relate. 10 out of 10 points and I would give even more if I could.

Show more Show less
9.3
Superb
30 reviews
Price from
£13
per night

Amaca Hostal

Santa Cruz de la Sierra

Amaca Hostal is located in Santa Cruz de la Sierra, 300 metres from Sacred Art Museum, 400 metres from Metropolitan Cathedral, and 400 metres from 24th of September Metropolitan Plaza. This guest house provides free private parking and a 24-hour front desk. Featuring family rooms, this property also provides guests with a sun terrace.

Show more Show less
8.6
Fabulous
12 reviews
Price from
£12
per night

Samailandia

Samaipata

Boasting garden views, Samailandia offers accommodation with patio, around 9.4 km from Samaipata Fort. Featuring a shared kitchen, this property also provides guests with a picnic area. The guest house features mountain views, a sun terrace, and free WiFi is available. Beautiful little courtyard and Maria the host was very nice

Show more Show less
8.4
Very good
62 reviews
Price from
£7
per night

Fonda Amboró

Samaipata

Providing city views, Fonda Amboró in Samaipata features accommodation and a garden. The property features mountain and garden views, and is 10 km from Samaipata Fort. There is free private parking and the property provides paid airport shuttle service.

Featuring a private bathroom with a shower and free toiletries, units at the guest house also offer free WiFi, while selected rooms come with a terrace. Beds were very good, spacious bedrooms, good shower and bathroom, fully equipped kitchen, delicious breakfast with homemade bread and jam, very nice attention of Adrian.

Show more Show less
8.2
Very good
72 reviews
Price from
£19
per night

Descanso Bueno

Santa Cruz de la Sierra

Offering city views, Descanso Bueno is an accommodation situated in Santa Cruz de la Sierra, 1.1 km from 24th of September Metropolitan Plaza and 1.4 km from Arenal Park. This guest house is 4.1 km from Güembé Biocentre and Guazú Ivaga Park and 15 km from Lomas de Arena National Park. Private parking can be arranged at an extra charge.

Show more Show less
8
Very good
2 reviews
Price from
£8
per night

Posada Express Complimentary Airport Shuttle & Card Payments Accepted

Isla del Mono

At the guest house, every unit has bed linen and towels.

The guest house offers an à la carte or American breakfast. Guests can relax in the on-site lounge, while packed lunches are also available upon request.

Show more Show less
9.7
Exceptional
3 reviews
Price from
£49
per night

Residencial Confort

Santa Cruz de la Sierra

The guest house is equipped with a flat-screen TV. The property offers city views.

Sacred Art Museum is 5.8 km from the guest house, while Metropolitan Cathedral is 6 km away. Viru Viru International Airport is 13 km from the property.

Show more Show less
7
Good
3 reviews
Price from
£10
per night

La Casona

Santa Cruz de la Sierra

At the guest house, units are fitted with a wardrobe, a flat-screen TV, a private bathroom, bed linen and towels.

Popular points of interest near the guest house include Arenal Park, Sacred Art Museum and Metropolitan Cathedral. The nearest airport is Viru Viru International, 14 km from La Casona, and the property offers a paid airport shuttle service. Very clean Nice friendly staff Good wifi Early check in

Show more Show less
7.8
Good
7 reviews
Price from
£24
per night

Most booked guest houses in Santa Cruz Region this month

FAQs about guest houses in Santa Cruz Region

  • Many families visiting Santa Cruz Region loved staying at Amaca Hostal, Hostel Serena and Fonda Amboró.

  • We make it quick and easy to book a guest house in Santa Cruz Region. Here’s what we offer:

    • Free cancellation on most stays
    • We Price Match
    • 24/7 customer support in 40+ languages

  • Hostel Serena, Travelero Hostel & Tours and Amaca Hostal are some popular guest houses in Santa Cruz Region.

  • Most guest houses on Booking.com offer free cancellation.

  • The average price per night for a guest house in Santa Cruz Region for this weekend is £95, based on current Booking.com prices.

  • There are 18 guest houses in Santa Cruz Region you can book on Booking.com.

  • Couples travelling in Santa Cruz Region loved staying at Hostel Serena, Fonda Amboró and Travelero Hostel & Tours.

  • Samailandia, Hostel Serena and Fonda Amboró have received great reviews from guests in Santa Cruz Region regarding the views from these guest houses

Guest Houses that guests love in Santa Cruz Region